Шрифт:
Интервал:
Закладка:
449
“Circadian interactions with cancer”, presented at the Society for Research on Biological Rhythms annual meeting, Amelia Island, Florida, 2002; M. C. Mormont and F. Levi, “Cancer chronotherapy: principles, applications, and perspectives”, Cancer 98:4, 881–882 (2003).
450
K. Buchi et al., “Circadian rhythms of cellular proliferation in the human rectal mucosa”, Gastroenterology 101, 410–415 (1991).
451
W. Hrushesky, “Circadian timing of cancer chemotherapy”, Science 228, 73–75 (1985). Такие же результаты были получены учеными при изучении детской лейкемии. В ходе обследования 118 больных детей выяснилось, что у тех из них, кто получал лекарство в вечерние часы, вероятность ремиссии была в три раза выше, чем у тех, кто получал лекарство утром. G. E. Rivard et al., “Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival”, Chronobiology International 10, 201–204 (1993).
452
Общепринятый в медицине критерий эффективности лечения злокачественных опухолей. – Ред.
453
F. Levi et al., “Chronotherapy of colorectal cancer metastases”, Hepatogastroenterology 48, 320–322 (2001). ГЛАВА 12
454
Владимир Набоков. Память, говори. Собр. соч.: в 5 томах. Т. 5. СПб., 1999.
455
Jerome M. Siegel, “The phylogeny of sleep”, presented at the Society for Research on Biological Rythms (SRBR) annual meeting, Amelia Island, Florida, 2002; интервью с Джеромом Сигелом, 15 февраля 2005 года; J. M. Siegel, “Clues to the functions of mammalian sleep”, Nature 437, 1264–1271 (2005).
456
J. A. Hobson, “Sleep is of the brain, by the brain, and for the brain”, Nature 437, 1254 (2005).
457
William C. Dement and Christopher Vaughan, The Promise of Sleep (New York: Dell, 2000).
458
C. B. Saper, “Hypothalamic regulation of sleep and circadian rhythms”, Nature 437, 1257–1263 (2005).
459
C. von Economo, “Sleep as a problem of localization”, Journal of Nervous and Mental Disorders 71, 249–259 (1930).
460
Saper, “Hypothalamic regulation of sleep and circadian rhythms”.
461
C. S. Colwell and S. Michel, “Sleep and circadian rhythms: do sleep centers talk back to the clock?”, Nature Neuroscience 6:10, 1005–1006 (2003); T. Deboer et al., “Sleep states alter activity of suprachiasmatic nucleus neurons”, Nature Neuroscience 6:10, 1086–1090 (2003); D. J. Dijk and C. A. Czeisler, “Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans”, Journal of Neuroscience 15, 3526–3538 (1995).
462
Dement and Vaughan, The Promise of Sleep, 18–22; Peretz Lavie, The Enchanted World of Sleep (New Haven: Yale University Press, 1996), 26 f; J. M. Siegel, “Why we sleep”, Scientific American, November 2003, 92–97.
463
K. J. Noonan, “Growing pains: are they due to increased growth during recumbency as documented in a lamb model?”, Journal of Pediatric Orthopaedics 24, 6 (2004).
464
J. V. Retey et al., “A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans”, Proceedings of the National Academy of Sciences 102, 15676–15681 (2005).
465
J. M. Siegel, “Clues to the functions of mammalian sleep”, Nature 437, 1264–1271 (2005).
466
Hobson, “Sleep is of the brain, by the brain, and for the brain”.
467
Siegel, “Why we sleep”.
468
T. A. Nielsen and P. Stenstrom, “What are the memory sources of dreaming?”, Nature 437, 1286–1289 (2005).
469
T. Nielsen, “Chronobiological features of dream production”, Sleep Medicine Reviews 8, 403–424 (2004).
470
T. Nielsen, “The typical dreams of Canadian university students”, Dreaming 13:4, 211 (2003).
471
Интервью с Тором Нильсеном, сентябрь 2006 года.
472
Интервью с Алленом Рехтшаффеном, 11 февраля 2005 года.
473
S. D. Youngstedt and C. E. Kline, “Epidemiology of exercise and sleep”, Sleep and Biological Rhythms 4:3, 215 (2006); см. также: S. D. Youngstedt et al., “No association of sleep with total daily physical activity in normal sleepers”, Physiology and Behavior 78, 395–401 (2003); S. D. Youngstedt, “Does exercise truly enhance sleep?”, Physician and Sport Medicine 25:10, 72–82 (1997).
474
J. Mu et al., “Ethanol influences on native T-type calcium current in thalamic sleep circuitry”, Journal of Pharmacology and Experimental Therapy 307:1, 197–204 (2003).
475
A. Rechtschaffen and B. M. Bergmann, “Sleep deprivation in the rat: an update of 1989 paper”, Sleep 25, 18–24 (2002).
476
Dement and Vaughan, The Promise of Sleep, 245.
477
Это и последующие высказывания Чарльза Чейслера взяты из: C. Czeisler, “Sleep: what happens when doctors do without it?”, Medical Center Hour, University of Virginia, March 1, 2006.
478
http://www.sleepfoundation.org/press/index.php?secid=&id=120.
479
Lavie, The Enchanted World of Sleep, 114; C. A. Czeisler, “Quantifying consequences of chronic sleep restriction”, Sleep 26:3, 247–248 (2003); H. P. A. Van Dongen et al., “The cumulative cost of additional wakefulness”, Sleep 26:2, 117 (2003).
480
D. F. Kripke et al., “Mortality associated with sleep duration and insomnia”, Archives of General Psychiatry 59, 131–136 (2002).
481
Van Dongen et al., “The cumulative cost of additional wakefulness”.
482
T. Roehrs et al., “Ethanol and sleep loss: a ‘dose’ comparison of impairing effects”, Sleep 26:8, 981–985 (2003); D. Dawson and K. Reid, “Fatigue, alcohol and performance impairment”, Nature 388, 235 (1997).
483
Czeisler, “Sleep: what happens when doctors do without it?”; L. K. Barger et al., “Extended work shifts and the risk of motor vehicle crashes among interns”, New England Journal of Medicine 352, 125–134 (2005).
484
Dement and Vaughan, The Promise of Sleep, 218.
485
“Breakthrough research on real-world driver behavior released”, press release, April 20, 2006, http://www.nhtsa.gov; editorial page, Nature Insight: Sleep 437, 1206 (2005).
486
Dement and Vaughan, The Promise of Sleep, 51–53; Russell Foster and Leon Kreitzman, Rhythms of Life (London: Profile Books, 2004), 208–209.
487
http://history.nasa.gov/rogersrep/v2appg.htm#g25.
488
Czeisler, “Quantifying consequences of chronic sleep restriction”.
489
K. Spiegel et al., “Effect of sleep deprivation on response to immunization”, Journal of the American Medical Association 288:12, 1471–1472 (2002).
490
K. Spiegel et al., “Impact of sleep debt on metabolic and endocrine function”, Lancet 354,