Зомби-клетки и как от них спастись

The Nobel Prize in Physiology or Medicine 2016, NobelPrize.org, Nobel Media AB 2020.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Takahashi K., Yamanaka S., Cell (2006) 126(4): 663–676.

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming, Ocampo A. et al., Cell (2016) 167(7): 1719–1733.e12.

Transplantation of mesenchymal stem cells from young donors delays aging in mice, Shen J., Tsai Y., Dimarco N., Long M., Sun X., Tang L., Scientific Reports (2011) 1.

Photoaged Skin Therapy with Adipose-Derived Stem Cells, Charles-de-Sá L. et al., Plastic & Reconstructive Surgery (2020) 145(6): 1037e–1049e.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in MiceXu M. et al., The journals of gerontology. Series A, Biological sciences and medical sciences (2017) 72(6): 780–785.

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan, Baker D. et al., Nature (2016) 530(7589): 184–189.

Senolytics improve physical function and increase lifespan in old age, Xu M., Pirtskhalava T., Farr J. N., Nat Med 24, 1246–1256 (2018).

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor, Coppé J., Patil C., Rodier F., Sun Y., Muñoz D., Goldstein J., Nelson P., Desprez P., Campisi J., PLoS biology (2008) 6(12).

Programmed cell senescence during mammalian embryonic development, Muñoz-Espín D. et al., Cell (2013) 155(5): 1104.

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA, Demaria M. et al., Developmental Cell (2014) 31(6): 722–733.

Apoptosis, Growth, and Aging, Cole L., Kramer P., Elsevier (2016), 63–66.

Senolytics improve physical function and increase lifespan in old age, Xu M. et al., Nature Medicine (2018) 24(8): 1246–1256.

Influence on Longevity of Blueberry, Cinnamon, Green and Black Tea, Pomegranate, Sesame, Curcumin, Morin, Pycnogenol, Quercetin, and Taxifolin Fed Iso-Calorically to Long-Lived, F1 Hybrid Mice, Spindler S., Mote P., Flegal J., Teter B., Rejuvenation Research (2013) 16(2): 143–151.

Fisetin is a senotherapeutic that extends health and lifespan, Yousefzadeh M. et al., EBioMedicine (2018) 36: 18–28.

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2, Latorre E., Torregrossa R., Wood M., Whiteman M., Harries L., Aging (2018) 10(7): 1666–1681.

Quercetin as an antiviral agent inhibits influenza a virus (IAV) Entry, Wu W., Li R., Li X., He J., Jiang S., Liu S., Yang J., Viruses (2015) 8(1).

Запасные детали биологии

The Nobel Prize in Physiology or Medicine 2016, NobelPrize.org, Nobel Media AB 2020.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Takahashi K., Yamanaka S., Cell (2006) 126(4): 663–676.

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming, Ocampo A. et al., Cell (2016) 167(7): 1719–1733.e12.

Transplantation of mesenchymal stem cells from young donors delays aging in mice, Shen J., Tsai Y., Dimarco N., Long M., Sun X., Tang L., Scientific Reports (2011) 1.

Photoaged Skin Therapy with Adipose-Derived Stem Cells, Charles-de-Sá L. et al., Plastic & Reconstructive Surgery (2020) 145(6): 1037e–1049e.

И сольются двое воедино

The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure, Crane J., Devries M., Safdar A., Hamadeh M., Tarnopolsky M., Journals of Gerontology — Series A Biological Sciences and Medical Sciences (2010) 65(2): 119–128.

Oxidative capacity and ageing in human muscle, Conley K., Jubrias S., Esselman P., Journal of Physiology (2000) 526(1): 203–210.

Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia, Picca A. et al., Biological Chemistry.

Measuring In Vivo Mitophagy, Sun N. et al., Molecular Cell (2015) 60(4): 685–696.

Exercise is mitochondrial medicine for muscle, Oliveira A., Hood D., Sports Medicine and Health Science (2019) 1(1): 11–18.

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging, Van Remmen H. et al., Physiological Genomics (2004) 16(1): 29–37.

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity Zhang Y. et al., Journals of Gerontology — Series A Biological Sciences and Medical Sciences (2009) 64(12): 1212–1220.

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans, Andreux P. A. et al., Nat Metab 1, 595–603 (2019).

Крупные умирают первыми

Growth curves for Laron syndrome, Laron Z., Lilos P., Klinger B., Archives of Disease in Childhood (1993) 68(6): 76.

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans, Guevara-Aguirre J. et al., Science Translational Medicine (2011) 3(70).

Life Extension in the Dwarf Mouse, Bartke A., Brown-Borg H., Current Topics in Developmental Biology (2004) 63: 189–225.

Height and survival at older ages among men born in an inland village in Sardinia (Italy), 1866–2006, Salaris L., Poulain M., Samaras T., Biodemography Soc Biol. 2012; 58(1): 1–13.

Is height related to longevity? Samaras T., Elrick H., Storms L., Life Sciences.

Physiology: Suppression of aging in mice by the hormone Klotho, Kurosu H. et al., Science (2005) 309(5742): 1829–1833.

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring, Vitale G. et al., Aging (2012) 4(9): 580–589.

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal, Zarse K. et al., Cell Metabolism (2012) 15(4): 451–465.